Tianhua Wang
Profile
Education
- PhD, Chemical and Biomolecular EngUniversity of Pennsylvania , United States
- M.Sc, BioInformaticsNational University of Singapore , Singapore
- B.Eng, Environmental Eng (1st class)National University of Singapore , Singapore
Publication
Journal Papers
Wang T, Hoi KM, Stöckmann H, Wan C, Sim LC, Shi Jie Tay, Poo CH, Woen S, Yang Y, Zhang P, Rudd PM. (2018) LC/MS-based Intact IgG and Released Glycan Analysis for Bioprocessing Applications Biotechnology Journal 13(4): e1700185
Zhang P, Woen S, Wang T, Liao RB, Zhao SC, Chen C, Yang Y, Song Z, Wormald MR, Yu C, Rudd P. (2016) Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs Drug Discovery Today 21(5):740-65
Ho SC, Wang T, Song Z, Yang Y. (2015) IgG Aggregation Mechanism for CHO Cell Lines Expressing Excess Heavy Chains. Molecular Biotechnology 57(7):625-34
Tan JG, Lee YY, Wang T, Yap MG, Tan TW, Ng SK.（2015） Heat shock protein 27 overexpression in CHO cells modulates apoptosis pathways and delays activation of caspases to improve recombinant monoclonal antibody titre in fed-batch bioreactors. Biotechnology Journal 10(5):790-800
Chng J, Wang T, Nian R, Lau A, Hoi K M, Ho S, Gagnon P, Bi X and Yang Y. (2015) Cleavage efficient 2A peptides for high level monoclonal antibody expression in CHO cells. MAbs 7(2):403-12
Zhang P, Wang T, Bardor M, and Song Z. (2013) Deciphering O-glycomics for the development and production of biopharmaceuticals. Pharmaceutical Bioprocessing 1(1):89-104
Shah PP, Wang T, Kaletsky RL, Myers MC, Purvis JE, Jing H, Huryn DM, Greenbaum DC Smith AB, Bates P, Diamond SL (2010) A Small-Molecule Oxocarbazate Inhibitor of Human Cathepsin L Blocks Severe Acute Respiratory Syndrome and Ebola Pseudotype Virus Infection into Human Embryonic Kidney 293T cells Molecular Pharmacology, 78(2):319-324, (co-1st author)
Zhang P, Tan DL, Heng D, Wang T, Mariati, Yang Y. and Song Z. (2010) A functional analysis of N-glycosylation-related genes on sialylation of recombinant erythropoietin in six commonly used mammalian cell lines. Metabolic Engineering 12(6):526-536.
Yun CY, Liu S, Lim SF, Wang T, Chung BY, Jiat Teo J, Chuan KH, Soon AS, Goh KS, Song Z. (2007) Specific inhibition of caspase-8 and -9 in CHO cells enhances cell viability in batch and fed-batch cultures. Metabolic Engineering 9(5-6):406-18.
Conferences
Wang T, Chew Y “Serotyping of Salmonella by MALDI-TOF” Society of Singapore Mass Spectrometry (SSMS) Aug 2019
Rao T, Li Y, Dong J, Hamada N, Wang T, Liang Y “Pharmacokinetic study of octreotide in mouse target tissues by imaging mass microscope (iMScope) with a novel relative exposure approach” Asian Oceanic Mass Spectrometry Conference (AOMSC) Dec 2017
Wang T, Hoi K, Stockmann H, Foong M, Zhang P, Lam KP and Rudd P “Development of an in-house high throughput and automated protocol for glycan profiling of biologics” poster presentation on Society of Laboratory Automation and Science (SLAS) annual meeting, Feb 2015
Wang T, Sim LC, Huo J, Bardor M and Lam KP “Mass Spectrometry-based glycan profiling for characterization of liver tissue from wild type and genetically modified mice mimicking hepatocellular carcinoma” poster presentation on Glyco 22, Jun 2013
Yusufi FNK, Wang T, Tan HY, Luo Y, Song Z, Bardor M and Lee DY “GlycoPath – a software toolbox for the identification and visual analysis of glycosylation in mammalian cell cultures” presentation on European Society for Animal Cell Technology, Jun 2013
Wang T and Diamond SL “Molecular modeling aided inhibitor design to target human cathepsin L has shown promise in finding therapeutics to block SARS and Ebola infection” presentation on American Institute of Chemical Engineers (AICHE) annual meeting, Nov 2011
Teaching
Teaching Modules
Pharmaceutical Engineering, BEng (Hons)
- PHE3231 - Expression Engineering
- PHE3020 - Pharmaceutical Analytical Techniques
Past
- CE3501 – Biochemical Process Engineering