Bernard LEUNG
Profile
SIT Appointments
- Associate Professor– Present
Education
- PhD (Immunology)University of Glasgow, UK. , United Kingdom
- BSc (Immunology)University of Glasgow, UK. , United Kingdom
Achievements
- NUS Office of Life Sciences Young Investigator Award
- Severe Acute Respiratory Syndrome Courage Star Award, Tan Tock Seng Hospital
Professional Memberships
- American Association of Immunologists
Research
Research Interests
-
Immunology
ResearchID: O-2409-2013; URL: http://www.researcherid.com/rid/O-2409-2013
-
Autoimmunity
ResearchID: O-2409-2013; URL: http://www.researcherid.com/rid/O-2409-2013
-
Allergy
ResearchID: O-2409-2013; URL: http://www.researcherid.com/rid/O-2409-2013
Current Projects
- Role of inflammatory mediators in the development of autoimmunity/allergyPresent
- Present
The role of immune system in ageing
- Present
Role of immunomodulators in experimental inflammatory conditions
Publication
Journal Papers
Tay, L., Y.Y. Ding, B.P. Leung, N.H. Ismail, A. Yeo, S. Yew, K.S. Tay, C.H. Tan, and M.S. Chong. 2015. Sex-specific differences in risk factors for sarcopenia amongst community-dwelling older adults. Age (Dordr). 37:121
Chong, M.S., L. Tay, N.H. Ismail, C.H. Tan, S. Yew, A. Yeo, R. Ye, B. Leung, and Y.Y. Ding. 2015. The case for stage-specific frailty interventions spanning community aging to cognitive impairment. J. Am. Med. Dir. Assoc. 16:1003.e13-e19
Lim, J.P., B.P. Leung, Y.Y. Ding, L. Tay, N.H. Ismail, A. Yeo, S. Yew, and M.S. Chong. 2015. Monocyte chemoattractant protein-1: a proinflammatory cytokine elevated in sarcopenic obesity. Clin. Interv. Aging 10:605
Tan, R.S., B. Ho, B.P. Leung, and J.L. Ding. 2014. TLR Cross-talk Confers Specificity to Innate Immunity. Int. Rev. Immunol. 33:443
Ting Tan, R.S., B. Lin, Q. Liu, L. Tucker-Kellogg, B. Ho, B.P. Leung, and J.L. Ding. 2013. The synergy in cytokine production through MyD88-TRIF pathways is coordinated with ERK phosphorylation in macrophages. Immunol. Cell Biol. 91:377
Goh, F.Y., K.L. Cook, N. Upton, L. Tao, L.C. Lah, B.P. Leung, and W.S. Wong. 2013. Receptor-interacting protein 2 gene silencing attenuates allergic airway inflammation. J. Immunol. 191:2691
Howe, H.S., K.O. Kong, B.Y. Thong, W.G. Law, F.L. Chia, T.Y. Lian, T.C. Lau, H.H. Chng, and B.P. Leung. 2012. Urine sVCAM-1 and sICAM-1 levels are elevated in lupus nephritis. Int. J. Rheum. Dis. 15:13
Lai, W.Q., F.L. Chia, and B.P. Leung. 2012. Sphingosine kinase and sphingosine 1-phosphate receptors: novel therapeutic targets of rheumatoid arthritis? Future Med. Chem. 4:727
Goh, F.Y., N. Upton, S. Guan, C. Cheng, M.K. Shanmugam, G. Sethi, B.P. Leung, and W.S. Wong. 2012. Fisetin, a bioactive flavonol, attenuates allergic airway inflammation through negative regulation of NF-kappaB. Eur. J. Pharmacol. 679:109
Lai, W.Q., W.S. Wong, and B.P. Leung. 2011. Sphingosine kinase and sphingosine 1-phosphate in asthma. Biosci. Rep. 31:145
Cheng, C., W.E. Ho, F.Y. Goh, S.P. Guan, L.R. Kong, W.Q. Lai, B.P. Leung, and W.S. Wong. 2011. Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway. PLoS One 6:e20932
Romero-Sanchez, C., H.K. Tsou, M.S. Jan, R.H. Wong, I.C. Chang, J. Londono, R. Valle-Onate, H.S. Howe, D. Yu, B.P. Leung, and J.C. Wei. 2011. Serum monocyte chemotactic protein-1 concentrations distinguish patients with ankylosing spondylitis from patients with mechanical lower back pain. J. Spinal Disord. Tech. 24:202
Crilly, A., S.E. Robertson, J.H. Reilly, J.A. Gracie, W.Q. Lai, B.P. Leung, P.F. Life, and I.B. McInnes. 2011. Phosphodiesterase 4 (PDE4) regulation of proinflammatory cytokine and chemokine release from rheumatoid synovial membrane. Ann. Rheum. Dis. 70:1130
Peng, J., Q. Yuan, B. Lin, P. Panneerselvam, X. Wang, X.L. Luan, S.K. Lim, B.P. Leung, B. Ho, and J.L. Ding. 2010. SARM inhibits both TRIF- and MyD88-mediated AP-1 activation. Eur. J. Immunol. 40:1738
Kong, K.O., A.W. Tan, B.Y. Thong, T.Y. Lian, Y.K. Cheng, C.L. Teh, E.T. Koh, H.H. Chng, W.G. Law, T.C. Lau, K.P. Leong, B.P. Leung, and H.S. Howe. 2009. Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus. Clin. Exp. Immunol. 156:134
Lai, W-Q., A.W. Irwan, H.H. Goh, A.J. Melendez, I.B. McInnes, and B.P. Leung. 2009. Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis. J. Immunol. 183:2097
Bao, Z., S. Guan, C. Cheng, S. Wu, S.H. Wong, D.M. Kemeny, B.P. Leung, and W.S. Wong. 2009. A novel antiinflammatory role for andrographolide in asthma via inhibition of the nuclear factor-kappaB pathway. Am. J. Respir. Crit. Care Med. 179:657