Get in Touch

With Ping LIAO

Name and email
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Associate Professor

Ping LIAO

Associate Professor
PhD (Neuro-oncology), National University of Singapore, Singapore
Cluster:
Health and Social Sciences
Email
Website

SIT Appointments

  • Associate Professor
    – Present

Education

  • PhD (Neuro-oncology)
    National University of Singapore , Singapore
  • Master of Surgery
    West China University of Medical Sciences , China
  • MBBS (Medicine)
    West China University of Medical Sciences , China

Achievements

  • Swee-Liew Wadsworth Research Gold Award
  • PhD Scholarship - NUS
    –

Professional Memberships

  • Member - Academic Medicine Research Institute (AMRI), DUKE-NUS Singhealth, 2012 – present
    – Present
chevron--up

Research Interests

  • Ischemic stroke, stroke therapy, cerebral edema, neuroprotection and neuroregeneration after cerebral damage
  • Transient Potential Channels and Calcium channels
  • Calcium homeostasis
chevron--up

Journal Papers

  • Low SW, Gao Y, Wei S, Chen B, Nilius B, Liao P. Development and characterization of a monoclonal antibody blocking human TRPM4 channel. Sci Rep. 2021 May 17;11(1):10411. IF 4.3

  • Wei S, Low SW, Poore CP, Chen B, Gao Y, Nilius B, Liao P. Comparison of Anti-oncotic Effect of TRPM4 Blocking Antibody in Neuron, Astrocyte and Vascular Endothelial Cell Under Hypoxia. Front Cell Dev Biol. 2020 Oct 19;8:562584. IF 5.9

  • Hazalin NAMN, Liao P, Hassan Z. TRPM4 inhibition improves spatial memory impairment and hippocampal long-term potentiation deficit in chronic cerebral hypoperfused rats. Behav Brain Res. 2020 Sep 1;393:112781. IF 3.3

  • Ahad MA, Kumaran KR, Ning T, Mansor NI, Effendy MA, Damodaran T, Lingam K, Wahab HA, Nordin N, Liao P, Müller CP, Hassan Z. Insights into the neuropathology of cerebral ischemia and its mechanisms. Rev Neurosci. 2020 Jul 28;31(5):521-538. IF 3.9

  • Zhang E, Liao P. Brain-derived neurotrophic factor and post-stroke depression.J Neurosci Res. 2020 Mar;98(3):537-548. IF 4.2

  • Alkaff SA, Radhakrishnan K, Nedumaran AM, Liao P, Czarny B. Nanocarriers for Stroke Therapy: Advances and Obstacles in Translating Animal Studies. Int J Nanomedicine. 2020 Jan 21;15:445-464. IF 6.4

  • Chen B, Gao Y, Wei S, Low SW, Ng G, Yu D, Tu TM, Soong TW, Nilius B, Liao P. TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke. Pflugers Arch. 2019 Dec;471(11-12):1455-1466. IF 3.7

  • Gao Y, Liao P. TRPM4 channel and cancer.Cancer Lett. 2019 Jul 10;454:66-69. IF 8.7

  • Chen B, Ng G, Gao Y, Low SW, Sandanaraj E, Ramasamy B, Sekar S, Bhakoo K, Soong TW, Nilius B, Tang C, Robins EG, Goggi J, Liao P. Non-Invasive Multimodality Imaging Directly Shows TRPM4 Inhibition Ameliorates Stroke Reperfusion Injury. Transl Stroke Res. 2019 Feb;10(1):91-103. IF 6.8

  • Loh KY, Wang Z, Liao P. Oncotic Cell Death in Stroke.Rev Physiol Biochem Pharmacol. 2019;176:37-64. IF 4.7

  • Damodaran T, Tan BWL, Liao P, Ramanathan S, Lim GK, Hassan Z. Clitoria ternatea L. root extract ameliorated the cognitive and hippocampal long-term potentiation deficits induced by chronic cerebral hypoperfusion in the rat. J Ethnopharmacol. 2018 Oct 5;224:381-390. IF 4.4

  • Hu Z, Li G, Wang JW, Chong SY, Yu D, Wang X, Soon JL, Liang MC, Wong YP, Huang N, Colecraft HM, Liao P, Soong TW. Regulation of Blood Pressure by Targeting CaV1.2-Galectin-1 Protein Interaction. Circulation. 2018 Oct 2;138(14):1431-1445. IF 30

  • Wang J, Li G, Yu D, Wong YP, Yong TF, Liang MC, Liao P, Foo R, Hoppe UC, Soong TW. Characterization of CaV1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and CaV1.2 exon 33 expressions in human heart failure. Channels (Austin). 2018 Jan 1;12(1):51-57. IF 2.1

  • Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, Yong TF, Wong YP, Hu Z, Huang H, Zhang G, Galupo MJ, Bian JS, Ponniah S, Trasti SL, See K, Foo R, Hoppe UC, Herzig S, Soong TW. Exclusion of alternative exon 33 of Ca(V)1.2 calcium channels in heart is proarrhythmogenic. Proc Natl Acad Sci U S A. 2017 May 23;114(21):E4288-E4295. IF 11.2

  • Hu Z, Wang JW, Yu D, Soon JL, de Kleijn DP, Foo R, Liao P, Colecraft HM, Soong TW. Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)beta Subunits in Cardiac Hypertrophy. Sci Rep. 2016 Oct 12;6:35247. IF 4.1

  • Qiu L, Ng G, Tan EK, Liao P, Kandiah N, Zeng L.Chronic cerebral hypoperfusion enhances Tau hyperphosphorylation and reduces autophagy in Alzheimer's disease mice. Sci Rep. 2016 Apr 6;6:23964. IF 4.1

  • Sun ZJ, Ng KH, Liao P, Zhang Y, Ng JL, Liu ID, Tan PH, Chong SS, Chan YH, Liu J, Davila S, Heng CK, Jordan SC, Soong TW, Yap HK. Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis. Am J Transplant. 2015 Dec;15(12):3229-38. IF 8.1

  • Liao P, Yu D, Hu Z, Liang MC, Wang JJ, Yu CY, Ng G, Yong TF, Soon JL, Chua YL, Soong TW. Alternative splicing generates a novel truncated Cav1.2 channel in neonatal rat heart. J Biol Chem. 2015 Apr 3;290(14):9262-72. IF 4.6

  • Zhang E, Liao P. Brain TRP channels and stroke. J Neurosci Res. 2015 Aug;93(8):1165-83. IF 4.2

  • Loh KP, Ng G, Yu CY, Fhu CK, Yu D, Vennekens R, Nilius B, Soong TW, Liao P. TRPM4 inhibition promotes angiogenesis after ischemic stroke. European Journal of Physiology (Pflugers Arch). 2014 Mar; 466(3):563-76. IF 4.86

  • Damodaran T, Hassan Z, Navaratnam V, Muzaimi M, Ng G, Müller CP, Liao P, Dringenberg HC. Time course of motor and cognitive functions after chronic cerebral ischemia in rats. Behav Brain Res. 2014 Sep 17;275C:252-258. IF 3.4

  • Sharma P, Liao P. Calcium ion Influx in Microglial Cells: Physiological and Therapeutic Significance. Journal of Neuroscience Research. 2014 Apr; 92(4):409-23. IF 4.2

  • Yu CY, Ng G, Liao P. Therapeutic antibodies in stroke. Translational Stroke Research. 2013;4:477-483. IF 2

  • Papanayotou C, Almeida I, Liao P (Joint First Author), Oliveira NM, et al. Calfacilitin is a novel calcium channel modulator essential for initiation of neural plate development. Nature Communications. 2013;4:1837. IF 10.

  • Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW. Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction. Circ Res. 2011 Nov 11;109(11):1250-8. IF 9.5

  • Zhang HY, Liao P, Yu D, Soong TW. Alternative splicing of Cav1.2 channels determines the diltiazem sensitivity between cardiac and smooth muscle. British Journal of Pharmacology 2010 Aug;160(7):1631-40. (Joint first author). IF 4.4

  • Soon JL, Liao P, Chua YL, Soong TW, Sin KY. Absence of Calcium Channel α1C-Subunit Mutation in Human Atrial Fibrillation. Asian Cardiovasc Thorac Ann. 2010 Aug; 18(4):349-53.

  • Liao P, Soong TW. Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency. European Journal of Physiology (Pflugers Arch) 2010 Jul;460(2):353-9. (Invited Review, Corresponding author) IF 4.46. This paper is one of the most frequently downloaded articles of this journal in 2010. IF 4.86

  • Liao P, Soong TW. Understanding alternative splicing of Cav1.2 calcium channels for a new approach towards individualized medicine. Journal of Biomedical Research. 2010, 24(3): 181-186. (Invited review)

  • Liao P, Li G, Yu D, Yong TF, Wang J, Soong TW. Molecular alteration of Cav1.2 calcium channel in chronic myocardial infarction. European Journal of Physiology (Pflugers Arch) 2009 Aug;458(4):701-11. IF 4.86

  • Liao P, Zhang HY, Soong TW. Alternative splicing of voltage-gated calcium channels: from molecular biology to disease. European Journal of Physiology (Pflugers Arch). 2009 Jul;458(3):481-7. Invited Review. IF 4.86

  • Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW. Differential Splicing Patterns of L-Type Calcium Channel Cav1.2 Subunit in Hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta.-MOL CELL RES. 2008 Jan;1783(1):118-30 IF 5.54

  • Tao J, Hildebrand ME, Liao P, Liang MC, Tan G, Li S, Snutch TP, Soong TW. Activation of corticotropin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels. Mol Pharmacol. 2008 Jun;73(6):1596-609 IF 4.88

  • Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL, Soong TW. A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J Biol Chem. 2007 Nov 30;282(48):35133-42. IF 4.77

  • Liao P, Yong TF, Liang MC, Yue DT, Soong TW. Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles. Cardiovasc Res. 2005 Nov 1;68(2):197-203. IF 6.0

  • Liao P, Yu D, Lu S, Tang ZZ, Liang MC, Zeng S, Lin W, Soong TW. Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels. J Biol Chem. 2004 Nov 26;279(48):50329-35. IF 4.77

  • Yi ZC, Liao P, You C, Yang KY. Intraventricular cavernous angioma. Hua Xi Yi Xue (Chinese), 1996, 11(1); 69-70

  • Shen Y, Yu D, Hiel H, Liao P, Yue DT, Fuchs PA, Soong TW. Alternative splicing of the Ca(v)1.3 channel IQ domain, a molecular switch for Ca2+-dependent inactivation within auditory hair cells. J Neurosci. 2006 Oct 18;26(42):10690-9. IF 7.1

Conferences

  • XIV European Meeting on Glial Cells in Health and Disease, 10 -13 July, 2019. Porto, Portugal. Hypoxia induces the expression of TRPV5 channel in astrocytes

  • 11th FENS Forum of Neuroscience 7-11 July, 2018. Berlin, Germany. Characterization of a TRPM4 blocking antibody in ischemic stroke.

  • XIII European Meeting on Glial Cells in Health and Disease, 8 -11 July, 2017. Edinburgh, United Kingdom. Expression of a novel TRP channel in Astrocytes: Implications for Ischemic Stroke

  • 10th FENS Forum of Neuroscience 2-6 July, 2016. Copenhagen, Denmark. Blocking endothelial TRPM4 channels with an antibody ameliorates ischemia reperfusion injury in stroke

  • Nov 26-28, 2015. Annual National Conference of Physiology and Pharmacology (APPICON-2015), India.

  • Nov 4-6, 2015. Universiti Sains Malaysia, CDR mini symposium on drug addiction and neurodegeneration “Brain disorders: current view and future perspectives”. Title: Targeting endothelial ion channels for vascular protection after stroke.

  • Nov 25, 2012. 国际神经病学中山高峰论坛•2012 暨中新帕金森病与运动障碍疾病诊疗新进展研讨会, Guangzhou, China. Title: Targeting vascular ion channels for ischemic stroke

  • July 2007 The 6th Scientific Conference on Cardiovascular Sciences Across the Strait., Xinjiang, P.R.China. Alternative splicing of Cav1.2 channels in normal and chronically infarcted rat heart

  • July 2004. 2nd Singapore International Neuroscience Conference, Singapore. Implications of functional splice variations of Cav1.2 calcium channels in physiology and ischemia

chevron--up