Valerio Isoni
Profile
Biography
I formally trained as a synthetic organic chemist at the University of Southampton, where I obtained a PhD.
The interest for large scale and industrial applications of green chemistry met my personal interest to move to Singapore in 2013, when I joined A*STAR as a scientist.
Over the years I have been working with both chemists and chemical engineers where both disciplines meet at the interface between academia and industry in areas such as process development & scale up, sustainability, green chemistry, process intensification, continuous processing.
I have a keen interest in testing promising sustainable technologies in the chemical space under simulated industrial conditions for proof-of-concept studies, demonstrations, but also in applied research on real industrial problems. I initiated, managed, and executed tens of research projects of varying complexity and size with both SMEs and MNCs in Singapore from Pharma and specialty chemicals industries.
Process intensification, water-based chemistry, mechanochemistry, continuous/flow chemistry, green chemistry methodologies are just some of the research topics I have been working on over the years and continue to be of interest.
SIT Appointments
- Associate professor– Present
Education
- Master of Science (Innovation)Singapore Management University , Singapore
- PhD (Organic Chemistry)University of Southampton , United Kingdom
- Master of Science (Organic Chemistry)Sapienza - University of Rome , Italy
- Bachelor of Science (Chemistry)Sapienza - University of Rome , Italy
Publication
Journal Papers
Xiao Qian Ng, Yu Zhao, and Valerio Isoni (2023), ''Scalable Synthesis of Antihistamines and Sensipar via Intensified Hydrogen Borrowing Methodology'', ACS Sustainable Chem. Eng. (10.1021/acssuschemeng.3c02803)
J.F. Reynes, V. Isoni, F. Garcia, (2023), ''Tinkering with Mechanochemical Tools for Scale up'', Angewandte Chemie (10.1002/ange.202300819)
C. Zhang, W. Dai, V. Isoni, A. Sourin, (2023), ‘’Automated Anomaly Detection for Surface Defects by Dual Generative Networks With Limited Training Data’’, IEEE Transactions on Industrial Informatics (DOI: 10.1109/TII.2023.3263517)
X. Q. Ng, C. S. Lim, M. W. Liaw, T. T. Quach, B. M. Yang, V. Isoni, J. Wu, Y. Zhao, (2023), ‘’ Direct access to chiral aliphatic amines by catalytic enantioconvergent redox-neutral amination of alcohols’’, Nature Synthesis (DOI: 10.1038/s44160-023-00264-z)
X.Q. Ng, M.H. Kang, R.W. Toh, V. Isoni, J. Wu, Y. Zhao, (2022), ‘’ A green access to supported cinchona alkaloid amide catalysts for heterogeneous enantioselective allylsilylation of aldehydes and process intensity evaluation in batch and flow’’, Green Synthesis and Catalysis (DOI: 10.1016/j.gresc.2022.07.004)
H. L. Chan, D. P. R. Len, S. Cheng, J. W. Kwek, V. Isoni, B. J. R. Thio (2022), ‘’ Understanding the Adsorption and Desorption of Sitagliptin Phosphate Monohydrate on SS2343, Glass, and PTFE Using QCM-D and Raman Spectroscopy’’, Langmuir (DOI: 10.1021/acs.langmuir.2c01418)
E. Colacino, V. Isoni, D. Crawford, F. García, (2021), ‘’Upscaling mechanochemistry: challenges and opportunities for sustainable industry’’, Trends in Chemistry (DOI: 10.1016/j.trechm.2021.02.008)
H. H. Khoo, R. M. Eufrasio-Espinosa, L. S.C. Koh, P. Sharratt, V. Isoni, (2019) “Sustainability assessment of biorefinery production chains: A combined LCA-supply chain approach, Journal of Cleaner Production (DOI: 10.1016/j.jclepro.2019.07.007)
H. H. Khoo, V. Isoni, P. Sharratt, (2018) “LCI data selection criteria for a multidisciplinary research team: LCA applied to solvents and chemicals”, Sustainable Production and Consumption (DOI: 10.1016/j.spc.2018.06.002)
V. Isoni, H. H. Khoo, D. G. A. Kumbang, P. Sharratt, (2018) “Biomass to levulinic acid: a techno-economic analysis and sustainability of biorefinery processes in Southeast Asia”, Journal of Environmental Management, (DOI: 10.1016/j.jenvman.2018.03.012)
V. Isoni, K. Mendoza, E. Lim, S.K. Teoh; (2017) ''Screwing NaBH4 through a Barrel without a Bang: A Kneaded Alternative to Fed-Batch Carbonyl Reductions", Organic Process Research & Development (DOI: 10.1021/acs.oprd.7b00107)
V. Isoni, L. Wong, H. H. Khoo, I. Halim, P. Sharratt (2016) “Q-SA√ESS: A methodology to help solvent selection for pharmaceutical manufacture at the early process development stage.”, Green Chemistry (DOI: 10.1039/C6GC02440H)
G. Righi, R. Pelagalli, V. Isoni, et al.;(2017) ''Synthesis, molecular modeling and biological evaluation of two new chicoric acid analogs'', Natural product research (DOI: 10.1080/14786419.2016.1169413)
H.H. Khoo, W.L. Ee, V. Isoni; (2016) ''Bio-chemicals from lignocellulose feedstock: sustainability, LCA and the green conundrum'', Green Chemistry (DOI:10.1039/C5GC02065D)
H.H. Khoo, L.L. Wong, J. Tan, V. Isoni, P. Sharratt; (2015) ''Synthesis of 2-methyl tetrahydrofuran from various lignocellulosic feedstocks: Sustainability assessment via LCA'', Resources, Conservation and Recycling (DOI:10.1016/j.resconrec.2014.12.013)
Books
Mechanochemistry and Emerging Technologies for Sustainable Chemical Manufacturing, (2023), CRC Press, ISBN 9781003178187
- Chapter 6: ''Mechanochemistry and Industry: Process Intensification and Beyond'', Valerio Isoni, 139-150
Life Cycle Assessment: New Developments And Multi-disciplinary Applications, (2022), World Scientific, ISBN: 978-981-124-581-7
- Chapter 5: ''Green Principles in Active Pharmaceutical Ingredient Manufacturing as Seen through the Lens of Life Cycle Assessment’’, Valerio ISONI, Hsien H. KHOO, and Alvin W. L. EE, 77-89