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With Wean Sin CHEOW

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Associate Professor

Wean Sin CHEOW

Programme Leader, Bachelor of Engineering with Honours in Pharmaceutical Engineering
Cluster Director, Food, Chemical and Biotechnology
PhD (Chemical & Biomolecular Engineering), Nanyang Technological University, Singapore
Cluster:
Food, Chemical and Biotechnology
Email

SIT Appointments

  • Cluster Director, Food, Chemical and Biotechnology
    – Present
  • Programme Leader, Bachelor of Engineering with Honours in Pharmaceutical Engineering
    – Present
  • Deputy Cluster Director, Food, Chemical and Biotechnology
    –
  • Associate Professor
    –
  • Assistant Professor
    –
  • Lecturer
    –

Education

  • PhD (Chemical & Biomolecular Engineering)
    Nanyang Technological University , Singapore
  • Bachelor of Engineering (Chemical and Biomolecular Engineering)
    Nanyang Technological University , Singapore

Achievements

  • Australasian Society for Computers in Learning in Tertiary Education (ASCILITE) Innovation Award
  • Elsevier Woman in Chemical Engineering Award – Runner Up
  • NanoFormulation 2012 (Barcelona) Travel Grant
  • Best Presentation Award (International Symposium on Exploring the Frontiers of Chemical and Biomedical Engineering, Singapore)
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Research Interests

  • Probiotics Encapsulation
  • Polymeric nanoparticles for controlled release
  • Particle Engineering, Powder Technology
  • Dry Powder for Pulmonary Delivery
  • Spray Drying

Current Projects

  • Cradle-To-Gate Life Cycle Assessments of API solid dosage from manufacturing aimed towards the development of green pharmaceutical excipient selection guide (GSK-EDB Trust Fund, co-PI)
    – Present

Past Projects

  • New Production Method for Naturally Healthier Spray Dried Low-Caloric Instant Beverages (SIT Ignition Grant, PI)
    –
  • Development of a Flipped Classroom Model for Laboratory Practicals in the Pharmaceutical Engineering Programme (SIT SALT Grant, PI)
    –
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Journal Papers

  • H. Yu, M.H. Nguyen, W.S. Cheow, and K. Hadinoto, "A new bioavailability enhancement strategy of curcumin via self-assembly nano-complexation of curcumin and bovine serum albumin", Mat Sci Eng C 75:25-33 (2017).

  • L.M. Lim, T.T. Tran, W.S. Cheow, K. Hadinoto, Re-evaluating the presumed superiority of amorphous nanoparticles over amorphous microscale solid dispersion in solubility enhancement of poorly soluble drugs“, Eur J Pharm Sci, 109: 455-463 (2017). 

  • W.S. Cheow, T.Y. Kiew and K. Hadinoto, "Effect of adding resistant and waxy starches on cell density and survival of encapsulated biofilm of Lactobacillus rhamnosus GG probiotics", LWT Food Sci and Technol 69: 497-505 (2016).

  • W.S. Cheow, T.Y. Kiew, and K. Hadinoto. Amorphous nanodrugs prepared by Complexation with Polysaccharides: Carrageenan versus Dextran Sulfate. Carbohydrate Polymers 117:549–558 (2015).

  • M. Kutscher, W.S. Cheow, V. Werner, U. Lorenz, K. Ohlsen,  L. Meinel, K. Hadinoto, O. Germershaus. Influence of salt type and ionic strength on self-assembly of polyelectrolyte-drug nanoplexes. Int J Pharm 486: 21–29 (2015).

  • T.Y. Kiew, W.S. Cheow, and K. Hadinoto. Preserving the Supersaturation Generation Capability of Amorphous  Drug-Polysaccharide Nanoparticle Complex After Freeze Drying. Int J Pharm 484:115–123 (2015).

  • W.S. Cheow, T.Y. Kiew, and K. Hadinoto, "Combining inkjet printing and amorphous nanonization to prepare personalized dosage forms of poorly-soluble drugs", Eur J Pharm Biopharm, 96: 314-321 (2015).

  • K. Hadinoto and W.S. Cheow. Nano-antibiotics in chronic lung infection therapy against Pseudomonas aeruginosa. Colloid Surface B 116:772–785 (2014).

  • T.Y. Kiew, W.S. Cheow and K. Hadinoto. Importance of biofilm age and growth medium on the viability of probiotic capsules containing Lactobacillus rhamnosusbiofilm. LWT Food Sci. and Technol. 59:956–963 (2014).

  • W.S. Cheow and K. Hadinoto. Antibiotic polymeric nanoparticles for biofilm-associated infection therapy. In G. Donelli (Ed.), Microbial Biofilms – Methods and Protocols, 2014. Humana Press. [Book Chapter]

  • W.S. Cheow, T.Y. Kiew, Y. Yang and K. Hadinoto. Amorphization strategy affects the stability and supersaturation profile of amorphous drug nanoparticles. Molecular Pharmaceutics 11:1611–1620 (2014).

  • K. Hadinoto, A. Sundaresan and W.S. Cheow. Lipid–polymer hybrid nanoparticles as a new generation drug and gene delivery platform: A review. Eur J Pharm Biopharm 85:427–443 (2013).

  • W.S. Cheow, R. Xu and K. Hadinoto. Towards sustainability: New approaches to nano-drug preparation. Curr Pharm Des 19:6229–6245 (2013).

  • W.S. Cheow and K. Hadinoto. Biofilm-like Lactobacillus rhamnosus probiotics encapsulated in alginate and carrageenan microcapsules exhibiting enhanced thermotolerance and freeze drying resistance. Biomacromolecules 14:3214–3222 (2013).

  • W.S. Cheow, T.Y. Kiew and K. Hadinoto. Controlled release of Lactobacillus rhamnosus biofilm probiotics from alginate-locust bean gum microcapsules. Carbohydrate Polymers 103:587–595 (2013).

  • Y. Yang, W.S. Cheow, and K. Hadinoto. Dry powder formulation of lipid-polymer hybrid nanoparticles via electrostatically-driven nanoparticle assembly onto microscale carrier particles. Int J Pharm 434:49–58 (2012).

  • Y. Wang, K. Kho, W.S. Cheow, and K. Hadinoto. A comparison between spray drying and spray freeze drying for dry powder inhaler formulation of drug-loaded lipid-polymer hybrid nanoparticles. Int J Pharm 424:98–106 (2012).

  • W.S. Cheow and K. Hadinoto. Green amorphous nanoplex as a new supersaturating drug delivery system. Langmuir 28:6265–6275 (2012).

  • W.S. Cheow and K. Hadinoto. Green preparation of antibiotic nanoparticle complex as potential antibiofilm therapeutics via self-assembly amphiphile-polyelectrolyte complexation with dextran sulfate. Colloid Surface B 92:55–63 (2012).

  • W.S. Cheow and K. Hadinoto. Self-Assembled amorphous drug-polyelectrolyte nanoparticle complex with enhanced dissolution rate and saturation solubility. J Colloid Interface Sci 367:518–526 (2012).

  • W.S. Cheow and K. Hadinoto. Lipid−polymer hybrid nanoparticles with rhamnolipid-triggered release capability as anti-biofilm drug delivery vehicles. Particuology 10:327–333 (2012).

  • W.S. Cheow, M.W. Chang, and K. Hadinoto. The roles of lipid in anti-biofilm efficacy of lipid-polymer hybrid nanoparticles encapsulating antibiotics. Colloid Surface A 389:158–165 (2011).

  • W.S. Cheow, M.L.L. Ng, K. Kho, and K. Hadinoto. Spray-freeze-drying production of thermally sensitive polymeric nanoparticles aggregates for inhaled drug delivery: Effect of freeze drying adjuvants. Int J Pharmaceutics 404:289–300 (2011).

  • W.S. Cheow and K. Hadinoto. Factors affecting drug encapsulation and stability of lipid-polymer hybrid nanoparticles. Colloid Surface B 85:214–220 (2011).

  • W.S. Cheow, M.W. Chang, and K. Hadinoto. Antibiotic loaded polymeric nanoparticle formulation for inhaled antibiotic therapy against bacterial biofilm. J Biomed Nanotechnol 6:391–403 (2010).

  • W.S. Cheow, S. Li, and K. Hadinoto. Spray drying formulation of hollow spherical aggregates of silica nanoparticles by experimental design. Chem Eng Res Des 88:673–685 (2010).

  • W.S. Cheow, M.W. Chang, and K. Hadinoto. Antibacterial efficacy of inhalable levofloxacin loaded polymeric nanoparticles against E. coli biofilm cells: The effect of antibiotic release profile. Pharm Res 27:1597–1609 (2010).

  • K. Kho, W.S. Cheow, R. H. Lie, and K. Hadinoto. Aqueous re-dispersibility of spray dried polycaprolactone nanoparticle aggregates for inhaled anti-biofilm therapy. Powder Technol. 203:432–439 (2010).

  • W.S. Cheow and K. Hadinoto. Enhancing encapsulation efficiency of highly water-soluble antibiotic in poly(lactic-co-glycolic acid) nanoparticles: Modifications of standard nanoparticle preparation methods. Colloid Surface A 37:79–86 (2010).

  • W.S. Cheow and K. Hadinoto. Preparations of dry powder therapeutic nanoparticle aerosols for inhaled drug delivery. Japan J Aer Res 25:155–165 (2010).

  • K. Hadinoto and W.S. Cheow. Hollow spherical nanoparticulate aggregates as potential ultrasound contrast agent: Shell thickness characterization. Drug Dev Ind Pharm 35:1167–1179 (2009).

Conferences

  • W.S. Cheow and K. Hadinoto. Amorphous drug nanoplex for saturation solubility enhancement, NanoFormulation, Barcelona, Spain, May 2012.

  • W.S. Cheow and K. Hadinoto. Dry Powder Nano-aggregates for Lung Biofilm Therapy by Spray-Freeze-Drying, 2011 Singapore Symposium on Drug Delivery Systems, Singapore. April 2011.

  • W.S. Cheow and K. Hadinoto. Inhaled antibiotic formulation for bacterial biofilm therapy, 4th Asian Conference on Colloid and Interface Science, Taiwan. Nov 2011.

  • W.S. Cheow and K. Hadinoto. Antibiotic-Loaded Nanoparticles for Inhalation: From Suspension to Dry Powder, 4th Asian Conference on Colloid and Interface Science, Tainan, Taiwan. Nov 2011.

  • W.S. Cheow and K. Hadinoto. Inhaled antibiotic formulation for bacterial biofilm therapy,The International Symposium on Exploring the Frontiers of Chemical and Biomedical Engineering, Singapore. May 2010.

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Teaching Modules

Pharmaceutical Engineering, BEng (Hons)

  • PHE1014 - Mass and Energy Balance
  • PHE1024 - Programming for Pharmaceutical Engineering
  • PHE2038 - Downstream Processing I
  • PHE3022 - Capstone Project
  • PHE3021 - Integrated Work Study Programme (IWSP)

Chemical Engineering, BSc

  • CE2502/3 - Chemical Engineering Design Course

Food Technology, BFoodTech(Hons)

  • FTE1013 - Mass and Energy Balance
  • FTE1023 - Programming for Engineering

Chemical Engineering, BEng (Hons)

  • CHE1014 - Mass and Energy Balances

Past

  • FTE2014 - Heat and Mass Conservation and Transfer
  • CE1301 - Advanced Math 1
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